Determining a Detectable Threshold of Signal Intensity in cDNA Microarray Based on Accumulated Distribution

Determining a detectable threshold of signal intensity in cDNA microarray based on accumulated distribution.

In microarray data mining, one of the key problems is how to handle weak signals. Based on a bent piecewise linear accumulated distribution generally found in the microarray data, a new detectable threshold finding method is proposed to filter genes with unreliable information in this paper. More reliable and reproducible data is produced for the subsequent data mining.

cDNA Microarray Data Normalization

Position of the fluorescent label is a crucial factor determining signal intensity in microarray hybridizations

A key issue in applications of short oligonucleotide-based microarrays is how to design specific probes with high sensitivity. Some details of the factors affecting microarray hybridization remain unclear, hampering a reliable quantification of target nucleic acids. We have evaluated the effect of the position of the fluorescent label [position of label (POL)] relative to the probe-target duple...

CORRIGENDUM Position of the fluorescent label is a crucial factor determining signal intensity in microarray hybridizations

Lei Zhang, Thomas Hurek and Barbara Reinhold-Hurek Nucleic Acids Res. (2005) 33, e166 The authors would like to apologize for an error in the Acknowledgements of their article. The correct Acknowledgement should read as follows: This work was linked to the CAG supported by the Land Bremen and the German Federal Ministry of Education and Research (BMBF) and was supported by a grant of the BMBF i...

Quantification of Parkinson Tremor Intensity Based On EMG Signal Analysis Using Fast Orthogonal Search Algorithm

The tremor injury is one of the common symptoms of Parkinson's disease. The patients suffering from Parkinson's disease have difficulty in controlling their movements owing to tremor. The intensity of the disease can be determined through specifying the range of intensity values of involuntary tremor in Parkinson patients. The level of disease in patients is determined through an empirical rang...